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PharmD-graded supplement reviews

Supplement Reviews

Honest, evidence-graded reviews of individual supplements — what the human data actually shows, the dose that matters, and whether it's worth your money. Each review is written by a licensed pharmacist and reviewed by a physician.

PrecisionOptimizeMetabolic HealthEvidence-based health, explained
Metabolic Health Moderate

Berberine vs. GLP‑1s: Is "Nature's Ozempic" Anything Like Ozempic?

Berberine is trending as "nature's Ozempic." What the human evidence actually shows on blood sugar, cholesterol, and weight — and why it's no substitute for GLP‑1 drugs.

SM
Sean Moshrefi, PharmD, MS
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PrecisionOptimizeLongevityEvidence-based health, explained
Longevity Moderate

Creatine for the Brain: What the Menopause and Cognition Research Actually Shows

Creatine is the most studied sports supplement on earth — but the newest research is about the brain. The human evidence on creatine for cognition, memory, and menopause, and what dose actually has data behind it.

SM
Sean Moshrefi, PharmD, MS
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PrecisionOptimizeLongevityEvidence-based health, explained
Longevity Moderate

NAD+ Precursors (NMN & NR): A PharmD Separates the Hype from the Evidence

NMN and NR supplements are everywhere in longevity circles. The actual human clinical trial data on NAD+ precursors — what they do, what the evidence shows, and whether they're worth taking.

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Sean Moshrefi, PharmD, MS
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PrecisionOptimizeLongevityEvidence-based health, explained
Longevity Moderate

Omega-3s: Fish Oil, EPA vs. DHA, and What the Evidence Actually Shows

Two large trials tested nearly identical omega-3 doses and reached opposite conclusions. Why they disagree, what the mineral oil placebo controversy means, and whether the fish oil in your cabinet does anything.

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Sean Moshrefi, PharmD, MS
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PrecisionOptimizeBiomarkersEvidence-based health, explained
Biomarkers Moderate

Vitamin D: How Much You Actually Need (and Why the Big Trials Changed the Answer)

Vitamin D was supposed to prevent cancer, heart disease, diabetes, and fractures. Then the randomized trials reported. What they actually found, why the 30 ng/mL target was never validated, and who still genuinely needs testing.

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Sean Moshrefi, PharmD, MS
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PrecisionOptimizeLongevityEvidence-based health, explained
Longevity Limited

Nattokinase: The Science and the Hype Behind the "Natural Blood Thinner"

Nattokinase, an enzyme from fermented soy (natto), is marketed as a natural clot-buster for heart health. Separating the real fibrinolytic science from the supplement hype — and the bleeding risks.

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Sean Moshrefi, PharmD, MS
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PrecisionOptimizeLongevityEvidence-based health, explained
Longevity

Are You Taking Too Many Supplements? A Pharmacist Audits the Longevity Stack

Longevity 'stacks' now run to dozens of pills a day. An audit of the supplement cabinet — what the large trials actually show, what's redundant, what carries real risk, and how to build a shorter, smarter list.

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Sean Moshrefi, PharmD, MS
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How we grade the evidence. Strong: Replicated human RCTs or large, consistent observational studies. Moderate–Strong: Solid human trials, but fewer or smaller than the top tier. Moderate: Limited human RCTs, or strong mechanism plus epidemiology. Limited: Mostly preclinical or early human data; outcomes not yet proven.How we grade the evidenceStrongReplicated human RCTs or large, consistent observational studiesModerate–StrongSolid human trials, but fewer or smaller than the top tierModerateLimited human RCTs, or strong mechanism plus epidemiologyLimitedMostly preclinical or early human data; outcomes not yet proven
Tiers run from the strongest human evidence (top) to the weakest (bottom). The badge on each supplement reflects the quality and quantity of human clinical data behind it — not how popular or heavily marketed it is.

Tackling a whole goal?

A review covers one supplement. A protocol compares your options for a goal.

Our supplement protocols line up the individually-reviewed compounds worth considering for one goal — with doses, evidence tiers, and drug-interaction notes, so you can pick what fits rather than take everything.

View Protocols →